GO:0004707 'MAP kinase activity'
| Cvterm details |
| Term id | GO:0004707 |
| Term name | MAP kinase activity |
| Term definition | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
| Comment |
Synonyms
ATP:protein phosphotransferase (MAPKK-activated) activity EXACT EC:2.7.11.24
Dp38 RELATED EC:2.7.11.24
ERK RELATED EC:2.7.11.24
extracellular signal-regulated kinase activity NARROW EC:2.7.11.24
LeMPK3 RELATED EC:2.7.11.24
MAP-2 kinase activity NARROW EC:2.7.11.24
MAPK RELATED EC:2.7.11.24
MBP kinase I activity NARROW EC:2.7.11.24
MBP kinase II activity NARROW EC:2.7.11.24
mitogen activated kinase activity EXACT
mitogen-activated protein kinase activity EXACT EC:2.7.11.24
myelin basic protein kinase activity NARROW EC:2.7.11.24
p38-2 RELATED EC:2.7.11.24
p38delta RELATED EC:2.7.11.24
p42 mitogen-activated protein kinase activity NARROW EC:2.7.11.24
p42mapk RELATED EC:2.7.11.24
p44mpk RELATED EC:2.7.11.24
PMK-1 RELATED EC:2.7.11.24
PMK-2 RELATED EC:2.7.11.24
PMK-3 RELATED EC:2.7.11.24
pp42 RELATED EC:2.7.11.24
pp44mapk RELATED EC:2.7.11.24
STK26 RELATED EC:2.7.11.24
"ATP:protein phosphotransferase (MAPKK-activated) activity" EXACT [EC:2.7.11.24]
"Dp38" RELATED [EC:2.7.11.24]
"ERK" RELATED [EC:2.7.11.24]
"ERK1" EXACT []
"ERK2" RELATED []
"extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24]
"LeMPK3" RELATED [EC:2.7.11.24]
"MAP kinase 1 activity" NARROW []
"MAP kinase 2 activity" NARROW []
"MAP-2 kinase activity" NARROW [EC:2.7.11.24]
"MAPK" RELATED [EC:2.7.11.24]
"MBP kinase I activity" NARROW [EC:2.7.11.24]
"MBP kinase II activity" NARROW [EC:2.7.11.24]
"mitogen activated kinase activity" EXACT []
"mitogen-activated protein kinase activity" EXACT [EC:2.7.11.24]
"MP kinase activity" NARROW []
"Mpk2" NARROW []
"myelin basic protein kinase activity" NARROW [EC:2.7.11.24]
"p38" NARROW []
"p38-2" RELATED [EC:2.7.11.24]
"p38delta" RELATED [EC:2.7.11.24]
"p42 mitogen-activated protein kinase activity" NARROW [EC:2.7.11.24]
"p42mapk" RELATED [EC:2.7.11.24]
"p44mpk" RELATED [EC:2.7.11.24]
"PMK-1" RELATED [EC:2.7.11.24]
"PMK-2" RELATED [EC:2.7.11.24]
"PMK-3" RELATED [EC:2.7.11.24]
"pp42" RELATED [EC:2.7.11.24]
"pp44mapk" RELATED [EC:2.7.11.24]
"SAPK2" NARROW []
"STK26" RELATED [EC:2.7.11.24]
"MAPK" RELATED [EC:2.7.11.24, PMID:20811974]
Definition dbxrefs
Related dbxrefs
GO:0008338
GO:0008339
GO:0016908
EC:2.7.11.24
KEGG:R00162
MetaCyc:2.7.11.24-RXN
Reactome:REACT_100829 "ERK5 is activated, Oryza sativa"
Reactome:REACT_104581 "ERK5 is activated, Arabidopsis thaliana"
Reactome:REACT_111161 "Activated ERK1/2 threonine-phosphorylate FRS2alpha., Homo sapiens"
Reactome:REACT_115393 "Phosphorylation of UBF-1
Reactome:REACT_12075 "ERK5 is activated, Homo sapiens"
Reactome:REACT_12418 "ERK5 is activated, Rattus norvegicus"
Reactome:REACT_180 "Phosphorylation of UBF-1
Reactome:REACT_25129 "Activation of p38MAPK by DSCAM, Homo sapiens"
Reactome:REACT_29583 "Phosphorylation of UBF-1
Reactome:REACT_30765 "Phosphorylation of UBF-1
Reactome:REACT_31584 "Phosphorylation of UBF-1
Reactome:REACT_80477 "ERK5 is activated, Danio rerio"
Reactome:REACT_82316 "Activation of p38MAPK by DSCAM, Rattus norvegicus"
Reactome:REACT_83043 "ERK5 is activated, Xenopus tropicalis"
Reactome:REACT_87321 "ERK5 is activated, Mus musculus"
Reactome:REACT_91897 "ERK5 is activated, Bos taurus"
Reactome:REACT_98528 "ERK5 is activated, Canis familiaris"
Reactome:REACT_99483 "ERK5 is activated, Dictyostelium discoideum"
Reactome:REACT_99569 "Phosphorylation of UBF-1
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GO:0003674 molecular_function 
is_a GO:0003824 catalytic activity is_a GO:0016740 transferase activity is_a GO:0016772 transferase activity, transferring phosphorus-containing groups is_a GO:0016301 kinase activity is_a GO:0004672 protein kinase activity is_a GO:0004674 protein serine/threonine kinase activity is_a GO:0004702 receptor signaling protein serine/threonine kinase activity 
is_a GO:0004707 MAP kinase activity is_a GO:0016773 phosphotransferase activity, alcohol group as acceptor is_a GO:0004672 protein kinase activity is_a GO:0004674 protein serine/threonine kinase activity is_a GO:0004702 receptor signaling protein serine/threonine kinase activity is_a GO:0004707 MAP kinase activity is_a GO:0060089 molecular transducer activity is_a GO:0004871 signal transducer activity is_a GO:0005057 receptor signaling protein activity is_a GO:0004702 receptor signaling protein serine/threonine kinase activity is_a GO:0004707 MAP kinase activity |
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